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Contact: Maggie McNamara Job title: Marketing Director Company: Gencor Contact: info@gencorpacific.com Visit us: www.gencorpacific.com
1How has the mental wellness/cognitive health space changed in the last two years, and how has your company innovated to support this shift?
The global brain-health supplement market is predicted to reach over $13 billion by 2028, with a CAGR of 8.0% to 2028.1
Countless people have experienced varying degrees of mental health challenges due to the pandemic in in these past three years. One in five Americans feel they are burdened with more stress2 and data also showed a sharp disparity between age and need for a renewed commitment to mental health1 . Up to 48% of adults aged 18 to 25 reported feeling anxious or depressed last June, with one-third saying they had an "unmet need" for therapy or counseling.3
This is where the supplement industry can have a profound impact in the cognitive health space - providing clinically researched ingredients that have a real effect on cognitive function, mood, stress and sleep are vital in this current market.
Gencor’s Calmaluma® and Levagen®+ are two brands that have received real interest in the market their ability to improve mood and sleep, respectively.
2In what areas of the cognitive health space are your ingredient(s) best suited for formulation, and in what type of applications?
HydroCurc® is the world’s most bioavailable curcumin that has been clinically proven to increase brain-derived neurotrophic factor – an important protein involved in memory and energy formation4. It solves the bioavailability and functional challenges of curcumin by using LipiSperse® - an award winning dispersion technology.
Adaptogens are active ingredients that may impact how your body deals with stress, anxiety and fatigue. Calmaluma® is a branded Caralluma Fimbriata extract, which has been clinically researched for its therapeutic potential in easing anxiety and stress in adults.5 Affron a branded Saffron extract, backed by 8 human clinical trials, is another adaptogen, having a huge impact in this space. The mental wellness effects seen in Affron® studies are supported by multiple “pathways”: its neuroprotective properties , impact on melatonin for those who can’t sleep, and ability to support a healthy inflammatory response. Lastly, sleep is essential for the mind and body, yet sleep disturbance is a common problem linked to a number of negative side effects such as poor cognitive function and a dampened immunity. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that can enhance sleep via potential interaction with the endocannabinoid system. Levagen+, the industry’s most bioavailable PEA, has been clinically proven to improve sleep by reducing the time taken to fall asleep and improve cognitive function upon awakening, without any drowsiness.
3How do you define your company’s point of differentiation and advantages in the market?
Gencor only has proprietary branded ingredients that all have multiple published human-clinical science. We also innovative delivery technologies that are backed by pharmacokinetic studies, increasing our ingredients efficacy and ability to provide functional benefits in areas related to the brain.
4What scientific research supports your ingredient(s) efficacy in this space?
Levagen+ has five human-clinical studies published and two that are under peer-review, along with seven human-clinical studies that are currently underway. Affron has eight published clinical studies. HydroCurc has five published clinical studies with several more ongoing. Calmaluma, our newest addition, has one human clinical trial published.
References: 1. https://www.prnewswire.com/news-releases/brain-health-supplements-market-size-worth-13-38-billion-by-2028-grand-view-research-inc-301214720.html 2. https://www.healio.com/news/psychiatry/20211206/americans-report-high-stress-levels-during-holiday-season 3. https://abcnews.go.com/Health/youth-mental-illness-soars-us-task-force-recommends/story?id=84036348 4. Tiekou Lorinczova, H.; Fitzsimons, O.; Mursaleen, L.; Renshaw, D.; Begum, G.; Zariwala, M.G. Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants 2020, 9, 645. https://doi.org/10.3390/antiox9080645 5. G. Kell, A. Rao, M. Katsikitis, A randomised placebo controlled clinical trial on the efficacy of Caralluma fimbriata supplement for reducing anxiety and stress in healthy adults over eight weeks, Journal of Affective Disorders, Volume 246, 2019, Pages 619-626, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2018.12.062.
Outside-the-box Adaptogens – fueling mental health and mood
As consumer interest in adaptogens grows, brands need to think outside the box to find novel, effective ingredients to manage stress, such as saffron and curcumin.
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Contact: Isabel Gómez Job title: Global Marketing Manager Company: Lubrizol Life Science Contact: nutraceuticals@lubrizol.com Visit us: www.lipofer.info
More than ever, consumers are looking for holistic solutions that support their physical, mental, and emotional well-being. This shift in consumers’ health concerns to a more preventative approach, has resulted in a demand for solutions for mental health including ways to improve sleep, mood and protect cognitive health for years to come.
Therefore, as consumers recognize the immediate and long-term importance on good cognitive health, they are looking for nutraceutical products that support their healthy ageing as a lifelong endeavor.
To meet the consumer´s demands, Lubrizol provides solutions for cognitive health and mental wellness, that include a wide offering of branded botanical and mineral ingredients with value-add and scientific evidence, thus enabling differentiated nutraceutical solutions to support several cognitive functions.
Lubrizol branded ingredients include: • NEWCAFF™ microcapsules, a sustained caffeine release with a clean taste for a long-lasting alertness, focus and concentration. • LIPOFER™ microcapsules, a bioavailable and stable source of iron to contribute to maintaining a normal cognitive function and to the reduction of tiredness and fatigue. • MAGSHAPE™ microcapsules, a concentrated source of magnesium for an active lifestyle that supports relaxation, stress relief and improves sleep quality. • ASTAGILE™ microcapsules*, a 100% natural solution based on natural microencapsulated astaxanthin with spirulina to improve memory and prevent cognitive decline. • CURCUSHINE™ microcapsules *, a bioavailable and soluble source of curcumin that can act as a natural sleeping helper and provides anti-aging benefits from within. A wide range of applications is possible with our added value branded ingredients including all kinds of dietary supplements such as sachets, syrups, chewable tablets, effervescent tablets, etc. and functional foods such as powder milk, yoghurts, etc. *Currently under development
Lubrizol’s unique science-backed nutraceutical ingredients provide a multi-functional holistic approach to address the different needs of cognitive and mental wellness. Our key point of differentiation is that all our branded ingredients are based on microencapsulation technology for an improved ingredient performance to support cognitive health.
Most minerals already have supporting claims associated to cognitive health. In our case we performed some in vivo tests to assess the protective cognitive effect of ASTAGILE™ microcapsules by performing an animal study where it was shown, it exerted a protective cognitive effect by reversing LPS-induced microglia activation.
Contact: Tony Gay Job title: Technical Sales Director, Nutrition Company: Prinova Europe Limited Contact: info@prinovaglobal.com Visit us: www.prinovaglobal.com
More and more consumers around the world are interested in cognitive health products. As a result, the demand for nootropics is increasing among a wide range of demographic groups. Nootropics are cognitive enhancers that can be incorporated into foods, beverages, and supplements to help improve functions like focus and memory. The percentage of global beverage launches with brain or nervous system claims has steadily increased over the past decade. As the market is still in its infancy, nootropic drinks are expected to witness substantial growth. Gaming and esports are becoming key drivers of the nootropic drink trend. Prinova offers a wide selection of ingredients that can be used in nootropic drinks, especially those that are popular with gamers.
There are growing opportunities to add brain-boosting benefits to functional beverages and meet growing consumer demand for convenience. Prinova offers many ingredients for beverages, from functional ingredients that benefit cognitive health, to formulation aiding ingredients, such as flavours and sweeteners. These ingredients can be used in all types of drinks, from fruit juices to powdered drinks, including energy drinks and other drinks intended for gamers. Prinova also offers ingredients suitable for gummies, a convenient format that is extremely popular among consumers and is a good alternative to drinks in the nootropic market.
Prinova has the right products and expertise to exploit the nootropic opportunity, with a wide range of unique ingredients, branded ingredients, and premix solutions. We offer a variety of value-added capabilities in the nootropics category, including full product development support for gummies, drinks, capsules, tablets, and ready-to-mix powders. We help our customers simplify their supply chain and accelerate their innovation pipeline with our custom premixes and ready-to-market blends for nootropics. Our full range of products and solutions help them react quickly and take advantage of new and emerging trends in this category.
Prinova offers a wide range of branded ingredients as the result of strategic partnerships and best-in-class scientific research. For example, Prinova is a key distributor for Sabinsa’s wide range of premium botanical ingredients, whose benefits for brain health are backed by scientific studies: Bacopin® can help reduce anxiety and mental fatigue, Curcumin C3® has been proven to support cognitive function, and Selenium SeLECT® is associated with reducing mental fatigue. Other Prinova’s nootropic ingredients include ginkgo biloba, ginseng, yerba mate, guarana, bacopa, and rhodiola. Prinova also offers vitamins and minerals with demonstrated nootropic benefits, such as B-vitamins, vitamin C, zinc, calcium, and magnesium. Our latest launch in the cognitive health area, AlphaTea™, is a natural source of L-Theanine, an amino acid found naturally in green tea. It improves cognitive performance (attention and reaction time improvement), eases anxiety, reduces stress and relieves insomnia. Contact us for more information about our products and services.
Cognitive focus: new opportunities in functional beverage markets
Wellbeing today is about much more than just physical health. People are increasingly seeking ways to support their cognitive health, too, with 66% of consumers globally now interested in cognitive health products