We provide an advanced, integrated high-throughput droplet sorting platform that accelerates antibody discovery. This platform supports high-performance screening against both soluble and transmembrane antigens. By harnessing plasma cells of the most popular species—not limited to mouse, rabbit, human, alpaca, etc.—whether fresh or in-vitro activated—the system enables direct acquisition of natural or genetically modified antibodies with exceptional specificity and affinity. Its sensitive, versatile , and high-throughput design further facilitates the discovery of functional antibodies, streamlining the development process from initial screening to therapeutic application.