Strategies Towards Green & Cost-Efficient Peptide Manufacturing

Eike-Fabian Sachs, PhD, Head of Development Frankfurt, CordenPharma International GmbH

Strategies Towards Green & Cost-Efficient Peptide Manufacturing

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Solid Phase Peptide Synthesis (SPPS) is most commonly applied to produce peptides on a large scale. Though most steps are already optimized, the Process Mass Intensity (PMI) of SPPS is still very high. In order to reduce the PMI of peptide synthesis, Corden Pharma is evaluating different strategies, including Flow and PAT, for scale-up on a production level. In combination with green alternatives for DMF, strategies to improve the manufacturing of peptides will be discussed.

Eike-Fabian Sachs, PhD, Head of Development Frankfurt, CordenPharma International GmbH
Eike-Fabian Sachs received his Ph.D. in organic chemistry from the Georg-August-University Göttingen. During his thesis he worked on the design and synthesis of DNA binding peptides with Professor Ulf Diederichsen. Eike joined CordenPharma in 2015 as a project chemist working on process development, optimization, innovation, and tech transfer for peptide APIs. In his current position, he is Head of Development for the CordenPharma site in Frankfurt, Germany.